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Scientists have revealed a key difference between the brains of alcohol-dependent and non-dependent rats, which may help develop personalised treatment for alcoholism and alcohol disorder.
When given alcohol, both groups of rats showed increased activity in a region of the brain called the central amygdala (CeA) – but this activity was due to two completely different brain signalling pathways.
Researchers from The Scripps Research Institute in the US gave non-dependent rats a dose of alcohol. They then engaged proteins called calcium channels and increased neuronal activity.
Neurons fired as the specific calcium channels at play, called L-type voltage-gated calcium channels (LTCCs), boosted the release of a neurotransmitter called GABA.
Researchers found that blocking these LTCCs reduced voluntary alcohol consumption in non-dependent rats.
However, in alcohol-dependent rats, researchers found decreased abundance of LTCCs on neuronal cell membranes, disrupting their normal ability to drive a dose of alcohol’s effects on central amygdala (CeA) activity.
Instead, increased neuronal activity was driven by a stress hormone called corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1), researchers said.
The team found that blocking CeA CRF1s reduced voluntary alcohol consumption in the dependent rats.
“There is a switch in the molecular mechanisms underlying the CeA’s response to alcohol (from LTCC- to CRF1-driven) as the individual transitions to the alcohol-dependent state,” said Professor Marisa Roberto of The Scripps Research Institute.
The findings could help researchers develop more personalised treatments for alcohol dependence, as they evaluate how a person’s brain responds to different therapeutics, Roberto said.
The study was published in the Journal of Neuroscience.
