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Using melatonin may provide better quality sleep compared to using an eye mask and earplugs in a noisy environment, according to new research.
The study was carried out on healthy subjects but could have future implications for intensive care unit (ICU) patients, researchers said.
Melatonin is the hormone secreted by the body to regulate sleep, usually in periods of darkness.
Synthetically produced melatonin is used to boost the body’s own melatonin levels to treat some sleep disorders, and sometimes as a means of overcoming jet lag.
In ICUs, disturbances throughout the night, caused by noise and light, have been linked to slower recovery. This has led clinicians to investigate ways of reducing sleep disturbances.
Researchers from Capital Medical University here recruited 40 healthy participants to study the effects simulated ICU conditions had on sleep patterns.
The research was conducted in the sleep lab of Fuzhou Children’s Hospital of Fujian Province in collaboration with Professor Ling Shen. For the first four nights all participants underwent a baseline/adjustment period.
During this time they slept in a sleep laboratory where on alternating nights, a recording from a typical night shift at an ICU was played and light levels were the same as in the hospital.
After the first four nights, the participants were randomly divided into four equal groups but continued to sleep in the simulated ICU.
The first group did not receive any sleep aid. The second were provided with eye masks and earplugs. The third group took 1mg of fast-release oral melatonin when going to bed.
The final group of participants was given a placebo. The participants did not know if they were receiving melatonin or placebo.
During the study period all participants’ melatonin levels were tested hourly by taking blood samples.
Anxiety levels and sleep quality were also evaluated by getting participants to self-evaluate the following morning.
It was found that all sleep patterns were disturbed by exposure to the simulated ICU environment. This resulted in feelings of anxiety and reduced quality of sleep.
Those participants that used either eye masks and earplugs or oral melatonin had improved sleep.
Those who took melatonin were found to have decreased awakenings during the night even compared to the eye mask and earplugs group.
The quality of the sleep was also found to be much improved for those taking melatonin, with reported lower anxiety levels and increased REM sleep — thought to be linked to improved cognitive restoration.
The study was published in the journal Critical Care.
